ITPKC (Inositol-Trisphosphate 3-Kinase C) is a Protein Coding gene. Diseases associated with ITPKC include Kawasaki Disease and Coronary Aneurysm . Among its related pathways are superpathway of inositol phosphate compounds and Metabolism .

3 Aug 2012 Although several genes have been proposed as causes of KD, 1,4,5- trisphosphate 3-kinase C (ITPKC) gene, which is significantly.

National Institutes of Health Create Alert The gene ITPKC may have Genomic and Proteomic products available from Sigma-Aldrich. The Parkinson’s disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release Daniel J. Apiccoa,b,1 , Evgeny Shlevkova, Catherine L. Nezicha , David T. Trana , Edward Guilmettec, 2019-12-07 · [PMID 18084290] ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. [PMID 20805785] Clinical Implication of the C Allele of the ITPKC Gene SNP rs28493229 in Kawasaki Disease: Association With Disease Susceptibility and BCG Scar Reactivation. The ITPKC gene provides instructions for making an enzyme called inositol 1,4,5-trisphosphate 3-kinase C. This enzyme helps limit the activity of immune system cells called T cells . T cells identify foreign substances and defend the body against infection.

Diseases associated with ITPKC include Kawasaki Disease and Coronary Aneurysm . Among its related pathways are superpathway of inositol phosphate compounds and Metabolism . Gene name: ITPKC (HGNC Symbol) Synonyms: IP3-3KC, IP3KC: Description: Inositol-trisphosphate 3-kinase C (HGNC Symbol) Chromosome: 19: Cytoband: q13.2: Chromosome location (bp) 40717103 - 40740860: Number of transcripts i HGNC:14897, ITPKC: MIM i: 606476, gene: neXtProt i: NX_Q96DU7: VEuPathDB i: HostDB:ENSG00000086544.2 We investigated the association between KD and single nucleotide polymorphisms (SNPs) in two candidate genes: inositol 1,4,5-triphosphate 3-kinase (ITPKC), a well-studied KD-associated gene, and solute carrier 11a1 (SLC11A1), which is associated with the hypersensitive reaction to the BCG strain in Koreans. ITPKC, human: GenomeRNAi i: 80271: Gene expression databases.

Tyrosine-protein kinase ITK/TSK also known as interleukin-2-inducible T-cell kinase or simply ITK, is a protein that in humans is encoded by the ITK gene. ITK is

Phenotype data for mouse gene Itpkc. Discover Itpkc's significant phenotypes, expression, images, histopathology and more. Data for gene Itpkc is all freely available for download. We previously identified 2 susceptibility genes for KD, inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) on 19q13.2 and caspase-3 (CASP3) on 4q34-35 through a genome-wide sib-pair study, followed Inositol 1,4,5-trisphosphate (IP3) 3-kinase C (ITPKC) is a negative regulator of the SOC channel-mediated signaling pathway.

ITPKC has 3,901 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 80 datasets.

One-way ANOVA test was used to calculate p values. genes associated with KD.5 One of the most interesting candi-date genes is inositol-1,4,5-triphosphate 3-kinase (ITPKC), which was first reported in Japan.6 Different single-nucleotide polymorphisms (SNPs) in the ITPKC gene have been reported in several countries.2,7 However, a previous study found no polymorphisms in ITPKC in Korean KD patients. Gene: Itpkc Log in to follow. Name. inositol 1,4,5-trisphosphate 3-kinase C. MGI ID. MGI:2442554. Synonyms. 9130023N17Rik.

Kawasaki disease. Directed by Professor Ho-Seong Kim. Keywords: Gene Expression, Hub Genes, RT-PCR, ROC Curve, WGCNA 1,4,5 -trisphosphate 3-kinase C (ITPKC) gene has been associated with enhanced 30 Nov 2018 As such, ITPKC, an upstream regulator of SOC entry, is a potential candidate gene for osteoclastogenesis as well. However, the genetic Rabbit Polyclonal ITPKC antibody Internal Region for ICC, IF, WB. ITPKC antibody (Inositol-Trisphosphate 3-Kinase C) (Internal Region) Primary Cellular Localization: Nucleus , Cytoplasm; Molecular Weight: 75 kDa; Gene ID: 80271. ITPKC (Inositol-trisphosphate 3-kinase C). active profile 1 user wants this gene increased, 0 users want it decreased Substances That Increase ITPKC. reaction in KD. We also reported that genes involved in Previous genetic polymorphism studies in trisphosphate 3-kinase C (ITPKC) gene, a gene upstream. Inositol-Trisphosphate 3-Kinase C (ITPKC) protein (Myc-DYKDDDDK Tag) L, itpkca, itpkc, LOC100354575, Itpkc; 背景: This gene encodes a member of the 7 Feb 2017 IP3 is phosphorylated to become IP4 by inositol 1,4,5-triphosphate 3-kinase C ( ITPKC) and negatively regulates T-cell receptor signal MEFV gene, and typically expressed with recurrent attacks of fever, serositis, rash , aphthous changes in The polymorphisms of the ITPKC gene were signifi-. An association has been identified with a SNP in the ITPKC gene, which codes an An additional factor that suggests genetic susceptibility is the fact that Kawasaki disease (KD) is an acute febrile systemic vasculitis, and the cause of KD is not well understood.
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Gene name, ITPKC.

Bgee i: ENSG00000086544, Expressed in lower esophagus mucosa and 209 other tissues: ExpressionAtlas i: ITPKC is one of 3 human genes that encode for an Inositol-trisphosphate 3-kinase.This gene that has been associated with Kawasaki disease. Kawasaki disease is an acute febrile illness that involves the inflammation of blood vessels throughout the body.
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12 Mar 2014 first indicated that a functional SNP (rs28493229) in the inositol 1,4,5- trisphosphate 3-kinase C (ITPKC) gene was associated with KD

Diseases associated with ITPKC include Kawasaki Disease and Coronary Aneurysm. Among its related pathways are superpathway of inositol phosphate compounds and Metabolism. ITPKC Acronym for "Inositol trisphosphate 3-kinase C" is a protein coding gene located on chromosome 19q13.2. The ITPKC gene encodes as one of three isoenzymes (ITPKA and ITPKB) for a member of the inositol 1,4,5-trisphosphate 3-kinase family. The ITPKC gene provides instructions for making one version (isoform) of the inositol 1,4,5-trisphosphate 3-kinase (ITPK) enzyme. This enzyme helps add a cluster of oxygen and phosphorus atoms (a phosphate group) to a molecule called Ins(1,4,5)P3 to produce a molecule called Ins(1,3,4,5)P4. ITPKC is one of 3 human genes that encode for an Inositol-trisphosphate 3-kinase.This gene that has been associated with Kawasaki disease.

ITPKC has 3,901 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 80 datasets.

365 patients were recruited in this study. The ITPKC gene was expressed in the mammary gland, but its expression was highest in breast cancer cells among other stromal cells in a bulk tumor. ITPKC expression was highest in TNBC, associated with its survival, and was its independent prognostic factor. ITPKC gene product. IP3-3KC, IP3KC. This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the itpkc inositol-trisphosphate 3-kinase C This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The gene ITPKC may have Genomic and Proteomic products available from Sigma-Aldrich.

No data available. Embryo viewer. N/A Other links. MGI Ensembl .